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Chronic stress is often blamed on high cortisol, but that explanation misses what is really happening beneath the surface. In this episode, we break down why cortisol is not the enemy, and how long-term stress quietly damages the systems that cortisol depends on to function properly.

We explore the concept of cortisol resistance and why so many people feel wired and exhausted at the same time. The conversation shifts inside the cell, where mitochondria play a central role in energy production, inflammation, and stress signaling. When stress is constant, mitochondria are pushed too hard for too long, leading to inefficient energy production and a body that never fully exits survival mode.

You’ll learn why NAD+ is a critical cellular resource that chronic stress rapidly depletes, and how low NAD+ levels can make recovery feel impossible even when sleep and nutrition improve. We also dive into mitochondrial-targeted research peptides like MOTS-C and SS-31, explaining how they are being studied for metabolic adaptation, mitochondrial protection, and stress resilience.

Rather than focusing on how to suppress cortisol, this episode reframes the problem as one of cellular repair. When energy systems recover, stress signals often calm naturally. If you’ve ever felt stuck in a cycle of fatigue, anxiety, inflammation, and poor sleep, this episode offers a deeper, more hopeful way to understand what may be happening inside your body.