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Cortisol is meant to help you wake up and handle stress during the day, not keep you alert when your body is desperate for rest. In this episode, we break down how chronic stress disrupts cortisol’s natural rhythm and why so many people feel exhausted all day but wired at night.

You’ll learn how elevated nighttime cortisol interferes with melatonin, deep sleep, and recovery, leading to fragmented sleep, early morning waking, and that familiar “wired but tired” feeling. We also explore why sleep issues driven by stress are not simply a matter of poor habits, but a sign that the nervous system is stuck in high alert mode.

The conversation then shifts to research-focused peptides often discussed in the context of cortisol-related sleep disruption. Semorelin is examined for its role in supporting deep sleep and recovery signaling that stress can suppress. DSIP is discussed for its connection to sleep architecture and the brain’s ability to enter deeper, more restorative sleep phases. Selank is explored for its effects on anxiety and stress pathways that can keep the mind racing at night.

This episode is designed for anyone who struggles with falling asleep, staying asleep, or waking up feeling unrefreshed despite getting enough hours in bed. It offers a clearer understanding of why sleep breaks down under chronic stress and how restoring biological signals may be the key to sleeping well again.